MADDE KULLANIM BOZUKLUKLARINDA GENETİK: BİR GÖZDEN GEÇİRME

MADDE KULLANIM BOZUKLUKLARINDA GENETİK: BİR GÖZDEN GEÇİRME

Yazarlar

  • Zeki Yüncü EGEBAM (Ege Üniversitesi Çocuk ve Ergen Alkol Madde Bağımlılığı Alkol ve madde araştırma ve Uygulama Merkezi)
  • Haluk A. Savaş Gaziantep Üniversitesi Tıp Fakültesi Psikiyatri A.D.

Anahtar Kelimeler:

Madde kullanım bozuklukları- genetik- ergenlerde

Özet

Önceleri madde kullanım bozukluklarının (MKB) gelişiminde çevresel, gelişimsel ve sosyal şartların etkili olduğu düşünülmekteydi. Ancak genetik alanında kaydedilen gelişmelerin ardından genetik nedenlerin oynadığı rol ön plana çıkmaya başlamıştır.
MKB gelişimi karmaşık bir süreçtir. Bu süreç maddeyi ilk deneme ile başlar, sürekli olarak kullanma ile devam eder ve bağımlılık gelişimi ile sonuçlanır. Genetik mekanizmaların bu sürecin farklı aşamalarına olan etkisi aydınlatılmalıdır.
Alkol, sigara, esrar, kokain bağımlılıklarının ailesel geçişi olduğu bildirilmiştir. Alkol kulanım bozukluklarının (AKB)genetiği diğer MKB genetiğine oranla daha sık çalışılmıştır. Bu çalışmaların sonucunda AKB ‘da genetik etkinin diğerlerine göre daha fazla olduğu bildirilmiştir.
MKB gelişiminde üzerinde uzlaşı sağlanan bir genetik yerleşim henüz saptanmamıştır. Bunun bir nedeni bu hastalığın oluşumunun poligenik nedenlere bağlanmasıdır. Bu durum hastalığın çok farklı fenotipik özelliklerle karşımıza çıkmasına neden olmaktadır. Bu farklı fenotipik özelliklerin ortaya konması genetik zeminin araştırılmasında yol göstericidir.

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Yayınlanmış

2007-12-01

Nasıl Atıf Yapılır

1.
Yüncü Z, Savaş HA. MADDE KULLANIM BOZUKLUKLARINDA GENETİK: BİR GÖZDEN GEÇİRME. J Depend [Internet]. 01 Aralık 2007 [a.yer 11 Ağustos 2025];8(3):146-52. Erişim adresi: https://bagimli.akademisyen.net/index.php/bagimli/article/view/156

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